Linked Life Data

1318807

Source:http://linkedlifedata.com/resource/pubmed/id/1318807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-7-21
pubmed:abstractText
1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) or ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-25 V, 10 Hz for 10 s, 1 ms pulse width) every 2 min, but also potentiated the contractile response to exogenous noradrenaline (5 mumol/L). The inhibited motor responses recovered rapidly and completely after washing out ranitidine. 3. 4-Aminopyridine (100 mumol/L) effectively reversed the partially inhibited (55% or greater) motor responses. 4. The results strongly suggest that ranitidine can inhibit adrenergic transmission in the anococcygeus muscle by a prejunctional mechanism with, presumably, consequent development of supersensitivity of the effector cells to noradrenaline.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle.
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Lower Kent Ridge.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't