Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-7-17
pubmed:abstractText
In order to study the importance of the immune status of the donor in the development of immunity after allogeneic bone marrow transplantation (BMT), we monitored 23 cytomegalovirus (CMV) antibody-positive BMT recipients for humoral and cellular immunity to CMV, of whom 12 had a CMV antibody-positive and 11 a CMV antibody-negative marrow donor. Lymphocyte proliferation to CMV recovered significantly earlier after BMT in recipients of marrow from a CMV+ donor (10.4 weeks after BMT) compared with the recipients of marrow from CMV- donors (16.7 weeks after BMT, P less than 0.05). This seemed to be specific, as lymphocyte proliferation to phytohaemagglutinin and Candida were not different between the to groups. IgM responses after active infection were seen in both groups, but initial IgG rises without IgM were seen only in recipients of marrow from CMV+ donors (P less than 0.05). Lymphocyte proliferative or humoral immune responses to CMV were not detected in any of the patients in a control group consisting of nine CMV- recipients. These results indicate that T cell memory to CMV is transferred with donor marrow from CMV+ donors, leading in most patients to direct IgG anti-CMV responses and to quicker recovery of cellular immunity to CMV.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2165110, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2168224, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2172297, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2297577, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2546299, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2824677, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2844333, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2850830, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2868294, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2882184, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-2994781, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-3040453, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-3549902, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-6143870, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-6150279, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-6260861, http://linkedlifedata.com/resource/pubmed/commentcorrection/1318805-6281647
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
506-11
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Evidence for transfer of cellular and humoral immunity to cytomegalovirus from donor to recipient in allogeneic bone marrow transplantation.
pubmed:affiliation
Department of Immuno-Haematology, University Hospital Utrecht, The Netherlands.
pubmed:publicationType
Journal Article