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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1976-8-2
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pubmed:abstractText |
Poly(L-lysine), a cationic polypeptide known to undergo specific interactions with acid mucopolysaccharides, is used as a macromolecular probe in an investigation into the structure of loose connective tissue. The polypeptide apparently binds, via an electrostatic mechanism, to the mucopolysaccharide component of the tissue, leading to a reduction in the swelling of the tissue. The polypeptide does not, however, have a deswelling effect on the tissue; the ultimate reduction in swelling is influenced by the absolute amount of polybase which enters the tissue during the swelling process. Dextran 2000 is found to have a dwelling effect on the tissue which is independent of the action of the polypeptide; this is suggestive of a large degree of independence between the collagen network and the mucopolysaccharide-containing matrix. The polypeptide, moreover, causes a reduction in the excluded volume of the tissue.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Hyaluronoglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Polylysine,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-8207
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
79-90
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:131677-Arginine,
pubmed-meshheading:131677-Connective Tissue,
pubmed-meshheading:131677-Dextrans,
pubmed-meshheading:131677-Diffusion,
pubmed-meshheading:131677-Hyaluronoglucosaminidase,
pubmed-meshheading:131677-Osmolar Concentration,
pubmed-meshheading:131677-Peptides,
pubmed-meshheading:131677-Polylysine,
pubmed-meshheading:131677-Sodium Chloride,
pubmed-meshheading:131677-Umbilical Cord
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pubmed:year |
1976
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pubmed:articleTitle |
The effect of a strongly-interacting macromolecular probe on the swelling and exclusion properties of loose connective tissue.
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pubmed:publicationType |
Journal Article
|