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pubmed-article:1316316pubmed:abstractTextWe examined the effect of lipopolysaccharide (LPS) on dextran bead-induced lung granulomas using LPS responder (C3H/HeN) and nonresponder (C3H/HeJ) mice. LPS augmented granuloma sizes, TNF-alpha and N-acetyl-beta-D-glucosaminidase levels of lung extracts in C3H/HeN, but not in C3H/HeJ mice. Granuloma macrophages of C3H/HeN mice produced higher levels of superoxide anion and TNF-alpha than those of C3H/HeJ mice. Taken together with our previous report that macrophages and macrophage-derived cytokines are essential for the development of lesions, the present results suggest that activation of macrophages plays an important role in the development and augmentation of pulmonary granulomas.lld:pubmed
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pubmed-article:1316316pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:1316316pubmed:articleTitleAugmentation of pulmonary foreign body granulomatous inflammation in mice by lipopolysaccharide: involvement of macrophage activation and tumor necrosis factor-alpha.lld:pubmed
pubmed-article:1316316pubmed:affiliationFirst Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.lld:pubmed
pubmed-article:1316316pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1316316pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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