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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-6-16
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pubmed:abstractText |
1. Five types of neoglycoprotein-coupled liposomes were prepared in order to investigate their potential utility as new types of drug-targeting devices which exploit cellular functions of carbohydrate-binding proteins. 2. These preparations were shown to be stable at 37 degrees C for 24 hr and at 7 degrees C over 4 months. 3. An inhibition assay in an in vitro system using human adenocarcinoma cells indicated the high affinity binding of neoglycoprotein-conjugated liposomes. The inhibitory potency correlated with both the type and the amount of immobilized neoglycoproteins on liposomes. 4. A tissue distribution assay in an in vivo system using Ehrlich solid tumor-bearing mice showed the feasibility of the application of [125I]neoglycoprotein-conjugated liposomes as drug-targeting devices, based on carbohydrate-protein interactions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0020-711X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-104
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:1316296-Carbohydrate Metabolism,
pubmed-meshheading:1316296-Carbohydrate Sequence,
pubmed-meshheading:1316296-Chromatography, High Pressure Liquid,
pubmed-meshheading:1316296-Colonic Neoplasms,
pubmed-meshheading:1316296-Drug Carriers,
pubmed-meshheading:1316296-Glycoproteins,
pubmed-meshheading:1316296-Humans,
pubmed-meshheading:1316296-Liposomes,
pubmed-meshheading:1316296-Male,
pubmed-meshheading:1316296-Molecular Sequence Data,
pubmed-meshheading:1316296-Organ Specificity,
pubmed-meshheading:1316296-Receptors, Cell Surface,
pubmed-meshheading:1316296-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Studies on carbohydrate-binding proteins using liposome-based systems--I. Preparation of neoglycoprotein-conjugated liposomes and the feasibility of their use as drug-targeting devices.
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pubmed:affiliation |
Industrial Products Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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