rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1992-6-11
|
pubmed:abstractText |
The addition of exogenous hepatocyte growth factor (HGF)/scatter factor (SF) to MDCK epithelial cells results in fibroblastic morphology and cell motility. We generated HGF/SF producing MDCK cells by transfection with an expression plasmid containing human HGF/SF cDNA. Production of HGF/SF by these cells induced a change from an epithelial to a fibroblastic morphology and increased cell motility. In addition, the HGF/SF producing cells acquired efficient anchorage-independent growth in soft agar but did not form tumors in nude mice. The morphological change and the stimulation of the anchorage-independent growth were prevented by anti-HGF/SF antibody, suggesting that the factor is secreted and then exerts its effects through cell surface receptors.
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1824837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1824873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1826653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1826837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1827130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1829089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1831266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1846706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2139229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2142596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2146117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2146276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2151613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2524251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2525565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2527367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2528952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2531289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2558106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2819873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2827008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2952888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3033290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3276728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3319692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3841349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-975091
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0021-9525
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
117
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
889-94
|
pubmed:dateRevised |
2010-9-7
|
pubmed:meshHeading |
pubmed-meshheading:1315783-Animals,
pubmed-meshheading:1315783-Cell Division,
pubmed-meshheading:1315783-Cell Movement,
pubmed-meshheading:1315783-Cell Polarity,
pubmed-meshheading:1315783-Cells, Cultured,
pubmed-meshheading:1315783-Dogs,
pubmed-meshheading:1315783-Epithelial Cells,
pubmed-meshheading:1315783-Gene Expression,
pubmed-meshheading:1315783-Growth Substances,
pubmed-meshheading:1315783-Hepatocyte Growth Factor,
pubmed-meshheading:1315783-Humans,
pubmed-meshheading:1315783-Immunologic Techniques,
pubmed-meshheading:1315783-RNA, Messenger,
pubmed-meshheading:1315783-Receptors, Cell Surface,
pubmed-meshheading:1315783-Transfection
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pubmed:year |
1992
|
pubmed:articleTitle |
Expression of a human hepatocyte growth factor/scatter factor cDNA in MDCK epithelial cells influences cell morphology, motility, and anchorage-independent growth.
|
pubmed:affiliation |
Institute for Liver Research, Kansai Medical University, Osaka, Japan.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|