Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-6-11
pubmed:abstractText
The addition of exogenous hepatocyte growth factor (HGF)/scatter factor (SF) to MDCK epithelial cells results in fibroblastic morphology and cell motility. We generated HGF/SF producing MDCK cells by transfection with an expression plasmid containing human HGF/SF cDNA. Production of HGF/SF by these cells induced a change from an epithelial to a fibroblastic morphology and increased cell motility. In addition, the HGF/SF producing cells acquired efficient anchorage-independent growth in soft agar but did not form tumors in nude mice. The morphological change and the stimulation of the anchorage-independent growth were prevented by anti-HGF/SF antibody, suggesting that the factor is secreted and then exerts its effects through cell surface receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1824837, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1824873, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1826653, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1826837, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1827130, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1829089, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1831266, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-1846706, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2139229, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2142596, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2146117, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2146276, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2151613, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2524251, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2525565, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2527367, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2528952, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2531289, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2558106, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2819873, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2827008, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-2952888, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3033290, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3276728, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3319692, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-3841349, http://linkedlifedata.com/resource/pubmed/commentcorrection/1315783-975091
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
889-94
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Expression of a human hepatocyte growth factor/scatter factor cDNA in MDCK epithelial cells influences cell morphology, motility, and anchorage-independent growth.
pubmed:affiliation
Institute for Liver Research, Kansai Medical University, Osaka, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't