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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-5-20
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pubmed:databankReference |
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pubmed:abstractText |
A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1314589-Activin Receptors,
pubmed-meshheading:1314589-Activins,
pubmed-meshheading:1314589-Amino Acid Sequence,
pubmed-meshheading:1314589-Animals,
pubmed-meshheading:1314589-Base Sequence,
pubmed-meshheading:1314589-Cloning, Molecular,
pubmed-meshheading:1314589-Gene Library,
pubmed-meshheading:1314589-Humans,
pubmed-meshheading:1314589-Inhibins,
pubmed-meshheading:1314589-Kinetics,
pubmed-meshheading:1314589-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:1314589-Molecular Sequence Data,
pubmed-meshheading:1314589-Radioligand Assay,
pubmed-meshheading:1314589-Receptors, Cell Surface,
pubmed-meshheading:1314589-Recombinant Proteins,
pubmed-meshheading:1314589-Restriction Mapping,
pubmed-meshheading:1314589-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Molecular cloning and binding properties of the human type II activin receptor.
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pubmed:affiliation |
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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