|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001455,
umls-concept:C0021641,
umls-concept:C0022245,
umls-concept:C0031640,
umls-concept:C0031715,
umls-concept:C0205251,
umls-concept:C0205263,
umls-concept:C0206131,
umls-concept:C0439596,
umls-concept:C0457784,
umls-concept:C1149866,
umls-concept:C1412691,
umls-concept:C1849508
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1992-5-15
|
|
pubmed:abstractText |
The cGI PDE in particulate fractions of differentiated adipocytes (but not control 3T3-L1 fibroblasts) was cross-reactive with a polyclonal antibody raised against the bovine adipose cGI PDE. The 3T3-L1 adipocyte cGI PDE is a 135 kDa protein which is phosphorylated in 32P-labeled cells in response to beta-agonist or insulin. These results indicate that the 3T3-L1 cGI PDE is similar in structure and hormonal regulation to the analogous enzyme in the rat adipocyte.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
31
|
|
pubmed:volume |
183
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1070-5
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:1314573-3T3 Cells,
pubmed-meshheading:1314573-Adipose Tissue,
pubmed-meshheading:1314573-Animals,
pubmed-meshheading:1314573-Blotting, Western,
pubmed-meshheading:1314573-Cell Differentiation,
pubmed-meshheading:1314573-Cross Reactions,
pubmed-meshheading:1314573-Insulin,
pubmed-meshheading:1314573-Isoproterenol,
pubmed-meshheading:1314573-Mice,
pubmed-meshheading:1314573-Phosphorylation,
pubmed-meshheading:1314573-Protein Kinases,
pubmed-meshheading:1314573-Quinolones
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Insulin and isoproterenol induce phosphorylation of the particulate cyclic GMP-inhibited, low Km cyclic AMP phosphodiesterase (cGI PDE) in 3T3-L1 adipocytes.
|
|
pubmed:affiliation |
Laboratory of Cellular Metabolism, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
