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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-5-18
|
| pubmed:abstractText |
The prevalence of lower genital neoplasia and Human Papilloma-virus-related genital lesions were evaluated in a cohort of 75 women with Human Immunodeficiency Virus type 1 (HIV-1) infection at different stages of HIV disease. The overall rate of cervical intraepithelial neoplasia (CIN) in the group studied was 29.3% (22/75). Eight out of 10 high-grade CIN lesions contained 'high-risk' HPV-DNA 16/18 and/or 31/35/51 as demonstrated by 'in situ' hybridization with biotinylated probes. Vulvar and/or perianal condylomata were histologically diagnosed in 14 patients (18.7%); nine of these biopsies contained detectable HPV-DNA which was always related to HPV 6/11. The rate of high-grade CIN in symptomatic HIV-infected patients was 28% (7/25) as compared to 6% (3/50) of the other cases (P = 0.022). CD4 lymphocyte counts, white blood cell counts, CD4+/CD8+ cell ratio and percentage of CD4+ lymphocytes were lower in patients with high-grade CIN in comparison to the patients with negative colposcopical and/or cytological examination. After adequate standard treatment (cryotherapy, electrocauterization, cold-knife conization) only one case of CIN 2 recurred during the 2 years of follow-up period. The prevalence of lower genital neoplasia and HPV-related lesions among HIV-infected women is high and seems to correlate with the severity of HIV disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0301-2115
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
235-41
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1314201-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1314201-Anus Diseases,
pubmed-meshheading:1314201-Cervix Uteri,
pubmed-meshheading:1314201-Condylomata Acuminata,
pubmed-meshheading:1314201-DNA, Viral,
pubmed-meshheading:1314201-Epithelium,
pubmed-meshheading:1314201-Female,
pubmed-meshheading:1314201-HIV Core Protein p24,
pubmed-meshheading:1314201-HIV-1,
pubmed-meshheading:1314201-Humans,
pubmed-meshheading:1314201-Nucleic Acid Hybridization,
pubmed-meshheading:1314201-Papillomaviridae,
pubmed-meshheading:1314201-Tumor Virus Infections,
pubmed-meshheading:1314201-Uterine Cervical Neoplasms,
pubmed-meshheading:1314201-Vulvar Diseases
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Prevalence, diagnosis and treatment of lower genital neoplasia in women with human immunodeficiency virus infection.
|
| pubmed:affiliation |
Department of Obstetrics & Gynaecology, University of Pavia, IRCCS Policlinico, Italy.
|
| pubmed:publicationType |
Journal Article
|