| pubmed-article:1313928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:1313928 | lifeskim:mentions | umls-concept:C0167178 | lld:lifeskim |
| pubmed-article:1313928 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1313928 | pubmed:dateCreated | 1992-5-14 | lld:pubmed |
| pubmed-article:1313928 | pubmed:abstractText | Human foamy virus (HFV) encodes the transcriptional transactivator bel1. The bel1 protein transactivates HFV long terminal repeat (LTR)-directed gene expression by recognizing a region in U3. It also transactivates human immunodeficiency virus type 1 (HIV-1) LTR-directed gene expression in transient transfection assays. To identify the specific region in HIV-1 LTR responsible for bel1 action, we examined the effect of bel1 on chloramphenicol acetyltransferase (CAT) gene expression in transfected cells with a series of mutant HIV-1 LTR/CAT plasmids. The region between -158 and -118 from the transcription initiation site, immediately upstream of the core enhancer element, was identified as responsible for the transactivation by bel1. In addition, bel1 transactivated a heterologous promoter when this region was positioned upstream of it in the sense and antisense orientations. Optimal transactivation of the HIV-1 LTR by bel1 did not require an intact TAR sequence, suggesting that the binding of tat to the TAR sequence is not a prerequisite for bel1 function in HIV-1 LTR-directed gene expression. In the region of the HIV-1 LTR that is necessary for the bel1-mediated transactivation, we have found a sequence which is conserved between HIV-1 and HFV. Our results suggest that the bel1 action on HIV-1 seems to be mediated by a specific DNA sequence which is shared by both the HIV-1 LTR and HFV LTR. | lld:pubmed |
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| pubmed-article:1313928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1313928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1313928 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1313928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1313928 | pubmed:month | May | lld:pubmed |
| pubmed-article:1313928 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1313928 | pubmed:author | pubmed-author:KimSS | lld:pubmed |
| pubmed-article:1313928 | pubmed:author | pubmed-author:LeeK JKJ | lld:pubmed |
| pubmed-article:1313928 | pubmed:author | pubmed-author:LeeA HAH | lld:pubmed |
| pubmed-article:1313928 | pubmed:author | pubmed-author:SHIEC SCS | lld:pubmed |
| pubmed-article:1313928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1313928 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1313928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1313928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1313928 | pubmed:pagination | 3236-40 | lld:pubmed |
| pubmed-article:1313928 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1313928 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1313928 | pubmed:articleTitle | Transactivation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by the human foamy virus bel1 protein requires a specific DNA sequence. | lld:pubmed |
| pubmed-article:1313928 | pubmed:affiliation | Department of Life Science, Pohang Institute of Science and Technology, Republic of Korea. | lld:pubmed |
| pubmed-article:1313928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1313928 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1313928 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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