Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-4-30
|
| pubmed:databankReference | |
| pubmed:abstractText |
A 190 bp insertion is associated with the white-eosin mutation in Drosophila melanogaster. This insertion is a member of a family of transposable elements, pogo elements, which is of the same class as the P and hobo elements of D. melanogaster. Strains typically have many copies of a 190 bp element, 10-15 elements 1.1-1.5 kb in size and several copies of a 2.1 kb element. The smaller elements all appear to be derived from the largest by single internal deletions so that all elements share terminal sequences. They either always insert at the dinucleotide TA and have perfect 21 bp terminal inverse repeats, or have 22 bp inverse repeats and produce no duplication upon insertion. Analysis by DNA blotting of their distribution and occupancy of insertion sites in different strains suggests that they may be less mobile than P or hobo. The DNA sequence of the largest element has two long open reading frames on one strand which are joined by splicing as indicated by cDNA analysis. RNAs of this strand are made, whose sizes are similar to the major size classes of elements. A protein predicted by the DNA sequence has significant homology with a human centrosomal-associated protein, CENP-B. Homologous sequences were not detected in other Drosophila species, suggesting that this transposable element family may be restricted to D. melanogaster.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Centromere Protein B,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotidyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Transposases
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0026-8925
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
232
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
126-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1313144-Amino Acid Sequence,
pubmed-meshheading:1313144-Animals,
pubmed-meshheading:1313144-Autoantigens,
pubmed-meshheading:1313144-Base Sequence,
pubmed-meshheading:1313144-Blotting, Southern,
pubmed-meshheading:1313144-Centromere Protein B,
pubmed-meshheading:1313144-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:1313144-DNA Transposable Elements,
pubmed-meshheading:1313144-DNA-Binding Proteins,
pubmed-meshheading:1313144-Drosophila melanogaster,
pubmed-meshheading:1313144-Female,
pubmed-meshheading:1313144-Male,
pubmed-meshheading:1313144-Molecular Sequence Data,
pubmed-meshheading:1313144-Nucleotidyltransferases,
pubmed-meshheading:1313144-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1313144-Restriction Mapping,
pubmed-meshheading:1313144-Sequence Alignment,
pubmed-meshheading:1313144-Transposases
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
The pogo transposable element family of Drosophila melanogaster.
|
| pubmed:affiliation |
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK.
|
| pubmed:publicationType |
Journal Article
|