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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-9-17
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pubmed:abstractText |
To investigate whether heterozygosity for a loss-of-function mutation in the gene encoding the alpha1 chain of type XI collagen (Col11a1) in mice (chondrodysplasia, cho) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mutation on articular cartilage in knee and temporomandibular (TM) joints.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2509-18
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:13130470-Animals,
pubmed-meshheading:13130470-Cartilage, Articular,
pubmed-meshheading:13130470-Collagen,
pubmed-meshheading:13130470-Collagen Type XI,
pubmed-meshheading:13130470-Collagenases,
pubmed-meshheading:13130470-Genotype,
pubmed-meshheading:13130470-Immunohistochemistry,
pubmed-meshheading:13130470-Knee Joint,
pubmed-meshheading:13130470-Matrix Metalloproteinase 13,
pubmed-meshheading:13130470-Matrix Metalloproteinase 3,
pubmed-meshheading:13130470-Mice,
pubmed-meshheading:13130470-Mice, Mutant Strains,
pubmed-meshheading:13130470-Movement,
pubmed-meshheading:13130470-Osteoarthritis, Knee,
pubmed-meshheading:13130470-Osteochondrodysplasias,
pubmed-meshheading:13130470-Temporomandibular Joint,
pubmed-meshheading:13130470-Tensile Strength
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pubmed:year |
2003
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pubmed:articleTitle |
Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho).
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pubmed:affiliation |
Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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