| pubmed-article:1312788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0001655 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0079652 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1312788 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1312788 | pubmed:issue | 3 Pt 1 | lld:pubmed |
| pubmed-article:1312788 | pubmed:dateCreated | 1992-4-23 | lld:pubmed |
| pubmed-article:1312788 | pubmed:abstractText | We evaluated whether the brain kallikrein-kinin system plays a role in the regulation of adrenocorticotropin (ACTH) release in rats. Intracerebroventricular (icv) injection of bradykinin (0.24 nmol) increased plasma immunoreactive ACTH (irACTH) levels (from 93 +/- 4 to 200 +/- 12 pg/ml, P less than 0.01). This effect was prevented by icv kinin antagonist at 15.4 nmol/h (from 98 +/- 5 to 108 +/- 6 pg/ml; not significant). The antagonist did not alter the increase in plasma irACTH levels induced by icv corticotropin-releasing factor (CRF), arginine vasopressin, or prostaglandin E2. Melittin (7 nmol/h icv) increased plasma irACTH from 95 +/- 4 to 268 +/- 7 pg/ml (P less than 0.01). This effect was prevented by icv kinin antagonist (15.4 nmol/h), kallikrein antibodies (13 pmol/h), or indomethacin (0.28 mmol/h). ACTH response to melittin was not altered by antagonists of CRF or vasopressin. Intra-arterial injection of insulin (0.3 IU/kg body wt) reduced plasma glucose levels to a similar extent in rats given icv kinin antagonist or vehicle; the ACTH response to insulin-induced hypoglycemia was slightly less in rats given kinin antagonist than in those given vehicle (55 +/- 5 vs. 86 +/- 4 pg/ml, P less than 0.05). The brain kallikrein-kinin system may play a role in the regulation of ACTH secretion in stimulated conditions. | lld:pubmed |
| pubmed-article:1312788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1312788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1312788 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1312788 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:AlagnaSS | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:GloriosoNN | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:MadedduPP | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:AnaniaVV | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:TonoloGG | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:TroffaCC | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:DemontisM PMP | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:VaroniM VMV | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:ParpagliaP... | lld:pubmed |
| pubmed-article:1312788 | pubmed:author | pubmed-author:FattaccioCC | lld:pubmed |
| pubmed-article:1312788 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1312788 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:1312788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1312788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1312788 | pubmed:pagination | E312-8 | lld:pubmed |
| pubmed-article:1312788 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1312788 | pubmed:meshHeading | pubmed-meshheading:1312788-... | lld:pubmed |
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| pubmed-article:1312788 | pubmed:meshHeading | pubmed-meshheading:1312788-... | lld:pubmed |
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| pubmed-article:1312788 | pubmed:meshHeading | pubmed-meshheading:1312788-... | lld:pubmed |
| pubmed-article:1312788 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1312788 | pubmed:articleTitle | Role of brain kallikrein-kinin system in regulation of adrenocorticotropin release. | lld:pubmed |
| pubmed-article:1312788 | pubmed:affiliation | Department of Clinical Medicine, Sassari University, Italy. | lld:pubmed |
| pubmed-article:1312788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1312788 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
