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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3 Pt 1
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pubmed:dateCreated |
1992-4-23
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pubmed:abstractText |
We evaluated whether the brain kallikrein-kinin system plays a role in the regulation of adrenocorticotropin (ACTH) release in rats. Intracerebroventricular (icv) injection of bradykinin (0.24 nmol) increased plasma immunoreactive ACTH (irACTH) levels (from 93 +/- 4 to 200 +/- 12 pg/ml, P less than 0.01). This effect was prevented by icv kinin antagonist at 15.4 nmol/h (from 98 +/- 5 to 108 +/- 6 pg/ml; not significant). The antagonist did not alter the increase in plasma irACTH levels induced by icv corticotropin-releasing factor (CRF), arginine vasopressin, or prostaglandin E2. Melittin (7 nmol/h icv) increased plasma irACTH from 95 +/- 4 to 268 +/- 7 pg/ml (P less than 0.01). This effect was prevented by icv kinin antagonist (15.4 nmol/h), kallikrein antibodies (13 pmol/h), or indomethacin (0.28 mmol/h). ACTH response to melittin was not altered by antagonists of CRF or vasopressin. Intra-arterial injection of insulin (0.3 IU/kg body wt) reduced plasma glucose levels to a similar extent in rats given icv kinin antagonist or vehicle; the ACTH response to insulin-induced hypoglycemia was slightly less in rats given kinin antagonist than in those given vehicle (55 +/- 5 vs. 86 +/- 4 pg/ml, P less than 0.05). The brain kallikrein-kinin system may play a role in the regulation of ACTH secretion in stimulated conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Kallikreins,
http://linkedlifedata.com/resource/pubmed/chemical/Kinins,
http://linkedlifedata.com/resource/pubmed/chemical/Melitten
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E312-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1312788-Adrenocorticotropic Hormone,
pubmed-meshheading:1312788-Amino Acid Sequence,
pubmed-meshheading:1312788-Analysis of Variance,
pubmed-meshheading:1312788-Animals,
pubmed-meshheading:1312788-Arginine Vasopressin,
pubmed-meshheading:1312788-Blood Glucose,
pubmed-meshheading:1312788-Bradykinin,
pubmed-meshheading:1312788-Brain,
pubmed-meshheading:1312788-Cerebral Ventricles,
pubmed-meshheading:1312788-Corticotropin-Releasing Hormone,
pubmed-meshheading:1312788-Dinoprostone,
pubmed-meshheading:1312788-Estradiol,
pubmed-meshheading:1312788-Female,
pubmed-meshheading:1312788-Injections, Intraventricular,
pubmed-meshheading:1312788-Insulin,
pubmed-meshheading:1312788-Kallikreins,
pubmed-meshheading:1312788-Kinins,
pubmed-meshheading:1312788-Melitten,
pubmed-meshheading:1312788-Molecular Sequence Data,
pubmed-meshheading:1312788-Ovariectomy,
pubmed-meshheading:1312788-Radioimmunoassay,
pubmed-meshheading:1312788-Rats,
pubmed-meshheading:1312788-Rats, Inbred Strains
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pubmed:year |
1992
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pubmed:articleTitle |
Role of brain kallikrein-kinin system in regulation of adrenocorticotropin release.
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pubmed:affiliation |
Department of Clinical Medicine, Sassari University, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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