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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0014597,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0680022,
umls-concept:C0929301,
umls-concept:C1235660,
umls-concept:C1458155,
umls-concept:C1510411,
umls-concept:C1517488
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pubmed:issue |
4
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pubmed:dateCreated |
1992-4-17
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pubmed:databankReference |
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pubmed:abstractText |
Expression of a 2.3-kb RNA species is induced in mammary tumors as a consequence of insertional mutagenesis at the int-3 locus by the mouse mammary tumor virus. The nucleotide sequence and biological activity of this mammary tumor-specific int-3 RNA species were determined. It contains an open reading frame which encodes a 57-kDa protein. The translated protein possesses six nearly contiguous 32-amino-acid repeats which are related to a similar motif in the Saccharomyces cerevisiae cdc-10-encoded cell cycle protein. In addition, the int-3 cdc-10 repeats are bounded by the PEST amino acid sequence motif which is commonly found in proteins having a rapid turnover and may represent sites for phosphorylation. The int-3 cdc-10 repeat sequences are 50% identical to a portion of the intracellular domain of the neurogenic Drosophila notch gene product. Activation of expression of a recombinant int-3 genomic DNA fragment encoding the 2.3-kb RNA species in HC11 mouse mammary epithelial cells in vitro induces anchorage-independent growth in soft agar.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-1764995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-1829648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-1831692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-1876833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-1876836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2083251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2137557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2162045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2180580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2185893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2203531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2234062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2278877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2317869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2402639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2429320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2548184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2645293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2649246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2689885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2758466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2821408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2876518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2957062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2959959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-2987824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3023708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3111720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3416834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3542227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3574458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-3935325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-4018034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6286831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6297757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6327073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312643-6587390
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2594-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1312643-Amino Acid Sequence,
pubmed-meshheading:1312643-Animals,
pubmed-meshheading:1312643-Base Sequence,
pubmed-meshheading:1312643-Cell Line,
pubmed-meshheading:1312643-Cell Transformation, Viral,
pubmed-meshheading:1312643-DNA, Viral,
pubmed-meshheading:1312643-Epithelial Cells,
pubmed-meshheading:1312643-Insect Hormones,
pubmed-meshheading:1312643-Mammary Glands, Animal,
pubmed-meshheading:1312643-Mammary Tumor Virus, Mouse,
pubmed-meshheading:1312643-Membrane Proteins,
pubmed-meshheading:1312643-Mice,
pubmed-meshheading:1312643-Molecular Sequence Data,
pubmed-meshheading:1312643-Multigene Family,
pubmed-meshheading:1312643-Proto-Oncogene Proteins,
pubmed-meshheading:1312643-Receptors, Cell Surface,
pubmed-meshheading:1312643-Receptors, Notch,
pubmed-meshheading:1312643-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1312643-Restriction Mapping,
pubmed-meshheading:1312643-Sequence Alignment,
pubmed-meshheading:1312643-Transcription, Genetic
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pubmed:year |
1992
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