Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-4-17
pubmed:databankReference
pubmed:abstractText
An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems requires knowledge of the diversity of their family members, their patterns of expression, and their pharmacological response to ligands. In this paper we report the isolation of a family of mouse RXR genes encoding three distinct receptors (RXR alpha, beta, and gamma). They are closely related to each other in their DNA- and ligand-binding domains but are quite divergent from the RAR subfamily in both structure and ligand specificity. Recently, we demonstrated that all-trans retinoic acid (RA) serves as a "pro-hormone" to the isomer 9-cis RA, which is a high-affinity ligand for the human RXR alpha. We extend those findings to show that 9-cis RA is also "retinoid X" for mouse RXR alpha, beta, and gamma. Trans-activation analyses show that although all three RXRs respond to a variety of endogenous retinoids, 9-cis RA is their most potent ligand and is up to 40-fold more active than all-trans RA. Northern blot and in situ hybridization analyses define a broad spectrum of expression for the RXRs, which display unique patterns and only partially overlap themselves and the RARs. This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:geneSymbol
RXR
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-44
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:1312497-Amino Acid Sequence, pubmed-meshheading:1312497-Animals, pubmed-meshheading:1312497-Base Sequence, pubmed-meshheading:1312497-Blotting, Northern, pubmed-meshheading:1312497-Carrier Proteins, pubmed-meshheading:1312497-Cloning, Molecular, pubmed-meshheading:1312497-DNA, pubmed-meshheading:1312497-Embryo, Mammalian, pubmed-meshheading:1312497-Mice, pubmed-meshheading:1312497-Molecular Sequence Data, pubmed-meshheading:1312497-Nuclear Proteins, pubmed-meshheading:1312497-Nucleic Acid Hybridization, pubmed-meshheading:1312497-Plasmids, pubmed-meshheading:1312497-RNA, Messenger, pubmed-meshheading:1312497-Receptors, Cell Surface, pubmed-meshheading:1312497-Receptors, Retinoic Acid, pubmed-meshheading:1312497-Retinoid X Receptors, pubmed-meshheading:1312497-Sequence Homology, Nucleic Acid, pubmed-meshheading:1312497-Substrate Specificity, pubmed-meshheading:1312497-Transcription, Genetic, pubmed-meshheading:1312497-Transcription Factors, pubmed-meshheading:1312497-Transcriptional Activation, pubmed-meshheading:1312497-Transfection, pubmed-meshheading:1312497-Tretinoin
pubmed:year
1992
pubmed:articleTitle
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
pubmed:affiliation
Salk Institute for Biological Studies, La Jolla, California.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't