| pubmed-article:1312491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:1312491 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:1312491 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1312491 | pubmed:dateCreated | 1992-4-21 | lld:pubmed |
| pubmed-article:1312491 | pubmed:abstractText | The roles of diabetes mellitus, insulin-like growth factor I and insulin in vascular smooth muscle proliferation in vivo were studied. Proliferation was induced by endothelial injury (balloon catheterization) of rat aorta, and was measured as 3H-thymidine incorporation into DNA. Levels of insulin-like growth factor I mRNA and insulin-like growth factor I receptor mRNA were measured with a solution hybridization assay. The increase in DNA synthesis was most pronounced 2 days after injury in both normal and diabetic rats and declined thereafter, but DNA synthesis in aortas from diabetic rats was lower throughout the time period studied. Levels of insulin-like growth factor I mRNA and the receptor mRNA were both increased in balloon catheterized aortas, and time-course studies showed an increase in receptor mRNA prior to the increase in insulin-like growth factor I mRNA. Diabetic rats were treated with equimolar concentrations of insulin (35 nmol/day) or insulin-like growth factor I (31 nmol/day) for 5 days. Insulin-like growth factor I increased DNA synthesis in injured aortas 2 days after injury without improving blood glucose, whereas the effect of insulin was associated with a decrease in blood glucose levels. In conclusion, vascular smooth muscle proliferation is impaired by diabetes and stimulated by insulin treatment. Insulin-like growth factor I infusion stimulates vascular smooth muscle proliferation without affecting blood glucose, and gene expressions of insulin-like growth factor I and its receptor are increased in proliferating vascular smooth muscle, indicating that insulin-like growth factor I and involved in vascular smooth muscle proliferation in vivo. | lld:pubmed |
| pubmed-article:1312491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1312491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1312491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1312491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1312491 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1312491 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:1312491 | pubmed:author | pubmed-author:CapronLL | lld:pubmed |
| pubmed-article:1312491 | pubmed:author | pubmed-author:ArnqvistH JHJ | lld:pubmed |
| pubmed-article:1312491 | pubmed:author | pubmed-author:BornfeldtK... | lld:pubmed |
| pubmed-article:1312491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1312491 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1312491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1312491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1312491 | pubmed:pagination | 104-8 | lld:pubmed |
| pubmed-article:1312491 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:1312491 | pubmed:meshHeading | pubmed-meshheading:1312491-... | lld:pubmed |
| pubmed-article:1312491 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1312491 | pubmed:articleTitle | In vivo proliferation of rat vascular smooth muscle in relation to diabetes mellitus insulin-like growth factor I and insulin. | lld:pubmed |
| pubmed-article:1312491 | pubmed:affiliation | Department of Pharmacology, Linköping University, Faculty of Health Sciences, Sweden. | lld:pubmed |
| pubmed-article:1312491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1312491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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