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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-4-9
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pubmed:abstractText |
We have shown previously that human sperm bind and enter leukocytes expressing surface HLA class II molecules. In the present study, mutant B lymphoblastoid cells and HLA-DR-transfected murine 3T3 fibroblasts are used to confirm that HLA class II molecules are somatic cell receptors for sperm. Further, for isolated HLA-DR expressed on murine cells, we show that sperm receptor activity requires the presence of sulfated carbohydrates. As carriers of multiple HLA-DR binding ligands, sperm may 1) mimic the target cell-activating effects of anti-DR antibody and 2) bind HIV through CD4-like or alternate receptors. By these or other mechanisms, sperm/somatic cell interactions in the female reproductive tract may affect fertility and potentiate the sexual transmission of AIDS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1718-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1311731-3T3 Cells,
pubmed-meshheading:1311731-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1311731-Animals,
pubmed-meshheading:1311731-B-Lymphocytes,
pubmed-meshheading:1311731-Cell Adhesion,
pubmed-meshheading:1311731-Cell Fusion,
pubmed-meshheading:1311731-Glycoconjugates,
pubmed-meshheading:1311731-HLA-DR Antigens,
pubmed-meshheading:1311731-Male,
pubmed-meshheading:1311731-Mice,
pubmed-meshheading:1311731-Receptors, Cell Surface,
pubmed-meshheading:1311731-Recombinant Proteins,
pubmed-meshheading:1311731-Spermatozoa,
pubmed-meshheading:1311731-Sulfates
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pubmed:year |
1992
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pubmed:articleTitle |
Binding of sperm to somatic cells via HLA-DR. Modulation by sulfated carbohydrates.
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pubmed:affiliation |
Department of Microbiology and Immunology, UCLA School of Medicine 90024.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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