Linked Life Data

1311230

Source:http://linkedlifedata.com/resource/pubmed/id/1311230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-4-2
pubmed:abstractText
It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded with either IL-1 (delivery rate 0.5, 2.0, or 4.0 micrograms/24 h, ip, for 1 week) or saline. At the end of the treatment the rats were decapitated, the adrenals were weighed, and the in vitro release of beta-endorphin (beta E) by the anterior pituitary and that of B by the adrenal gland were measured. Continuous administration of 2.0 and 4.0 micrograms IL-1/24 h resulted in a persistent increase in plasma ACTH and B concentrations compared to the levels in saline-infused rats, with peak levels on the first day of administration. In addition, adrenal weights of IL-1 rats were significantly higher than those of saline rats. The 4.0-micrograms IL-1/day in vivo treatment induced an increase in spontaneous in vitro secretion of beta E and B, while the in vitro responses of the pituitary (to CRF) and the adrenal (to ACTH) of animals treated in vivo with IL-1 were significantly diminished. IL-1 at a dose of 0.5 microgram failed to affect plasma ACTH and B values, adrenal weight, and in vitro beta E and B secretion. Chronic infusion of rats with 4.0 micrograms IL-1/day induced prolonged fever, whereas at lower doses of IL-1 (2.0 and 0.5 micrograms), temperatures were elevated only on the first 2 days of infusion. IL-1 at doses of 2.0 and 4.0 micrograms/day induced suppression of body weight gain on the first 2 days of the treatment period compared to saline treatment. Plasma norepinephrine and/or epinephrine concentrations were raised only on day 1 of the 2.0- and 4.0-micrograms IL-1 experiments. Thus, the observed effects of IL-1 on the hypothalamo-pituitary-adrenal axis probably do not result merely from stress induced by the treatment. Taken together, our data show the potential of IL-1 to induce a dose-dependent and long term activation of the pituitary-adrenal axis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1153-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1311230-Adrenal Glands, pubmed-meshheading:1311230-Adrenocorticotropic Hormone, pubmed-meshheading:1311230-Animals, pubmed-meshheading:1311230-Body Temperature, pubmed-meshheading:1311230-Body Weight, pubmed-meshheading:1311230-Catecholamines, pubmed-meshheading:1311230-Corticosterone, pubmed-meshheading:1311230-Dose-Response Relationship, Drug, pubmed-meshheading:1311230-Eating, pubmed-meshheading:1311230-Estradiol, pubmed-meshheading:1311230-Infusion Pumps, pubmed-meshheading:1311230-Interleukin-1, pubmed-meshheading:1311230-Longitudinal Studies, pubmed-meshheading:1311230-Male, pubmed-meshheading:1311230-Organ Size, pubmed-meshheading:1311230-Pituitary Gland, pubmed-meshheading:1311230-Pituitary-Adrenal System, pubmed-meshheading:1311230-Prolactin, pubmed-meshheading:1311230-Radioimmunoassay, pubmed-meshheading:1311230-Rats, pubmed-meshheading:1311230-Rats, Inbred Strains
pubmed:year
1992
pubmed:articleTitle
Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies.
pubmed:affiliation
Department of Medicine, St. Radboud Hospital, University of Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't