Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-16
pubmed:abstractText
Transient gene expression studies have indicated that human cytomegalovirus (HCMV) specifically transactivates the human immunodeficiency virus (HIV) long terminal repeat (LTR). We show here, by a specific mutational analysis, that only the TATA box region is obligatory for transactivation of the HIV-1 LTR by HCMV. Similarly, this element is also sufficient for transactivation by either the HCMV 72-kDa major immediate-early 1 (IE1) or 80-kDa IE2 gene product independently. However, deletion of a 10-bp region from the minimal responsive element, 5' to the TATA box, dramatically reduced the level of HCMV 72-kDa IE1 or 80-kDa IE2 transactivation, indicating a crucial role for this element in transactivation. Whereas inclusion of the TAR element or Sp1 sites on this 10-bp-deleted minimal promoter had no effect on the removal of IE1 transactivation, TAR and Sp1 elements did compensate for the 10-bp element in transactivation by IE2 and HCMV. Consequently, the sequence requirements of the HIV-1 LTR for transactivation by HCMV can be reproduced by these IE1 and IE2 gene products of HCMV.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-11892819, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-1647074, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2001592, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2006421, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2142019, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2149119, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2157038, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2157043, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2158700, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2159554, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2193231, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2432602, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2436392, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2446005, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2527315, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2529378, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2536844, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2538828, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2549725, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2553266, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2556267, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2556854, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2573513, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2654643, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2705309, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2724417, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2823252, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2823260, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2825201, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2830574, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2830675, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2830991, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2831401, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2838967, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2845125, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2967970, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2981427, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2982104, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2985953, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2986374, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2987842, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-2994217, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3004967, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3027377, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3031512, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3186723, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3313729, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3340539, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3498942, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-3639669, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-6286831, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-6294651, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-6414718, http://linkedlifedata.com/resource/pubmed/commentcorrection/1310765-6960240
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/IE1 protein, cytomegalovirus, http://linkedlifedata.com/resource/pubmed/chemical/IE2 protein, Cytomegalovirus, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/UL115 protein, Human herpesvirus 5, http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins, http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Cytomegalovirus, http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Human..., http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein O, cytomegalovirus
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:geneSymbol
c-fos, c-myc, hps
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1543-50
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
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