| pubmed-article:1310692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0022677 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0052088 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:1310692 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:1310692 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1310692 | pubmed:dateCreated | 1992-3-18 | lld:pubmed |
| pubmed-article:1310692 | pubmed:abstractText | To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. The chronic effect of PMA was inhibited by 10 nM actinomycin D or 7 microM cycloheximide. Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. This latter effect may mediate increased Na/H antiporter activity in a number of chronic conditions. | lld:pubmed |
| pubmed-article:1310692 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1310692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1310692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1310692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1310692 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1310692 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1310692 | pubmed:author | pubmed-author:MillerR TRT | lld:pubmed |
| pubmed-article:1310692 | pubmed:author | pubmed-author:HorieSS | lld:pubmed |
| pubmed-article:1310692 | pubmed:author | pubmed-author:AlpernR JRJ | lld:pubmed |
| pubmed-article:1310692 | pubmed:author | pubmed-author:MokEE | lld:pubmed |
| pubmed-article:1310692 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1310692 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1310692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1310692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1310692 | pubmed:pagination | 365-72 | lld:pubmed |
| pubmed-article:1310692 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:meshHeading | pubmed-meshheading:1310692-... | lld:pubmed |
| pubmed-article:1310692 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1310692 | pubmed:articleTitle | Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. | lld:pubmed |
