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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-2-18
pubmed:abstractText
The low-affinity receptor for IgE (Fc epsilon RII/CD23) is a cell surface glycoprotein that plays a role in both cellular immunity and allergic inflammation. Its extracellular IgE-binding domain bears homology to C-type animal lectins, and the protein is, therefore, classified as a member of this superfamily. We predict that this lectin-like domain is separated from the cell membrane by an extensive region of alpha-helical coiled-coil structure, based upon sequence comparisons with tropomyosin, the archetypal alpha-helical coiled-coil structure, and detection of characteristic heptad repeats. Analysis of other receptor protein sequences identified a similar structural motif in other membrane-bound members of the C-type lectin superfamily, including the asialoglycoprotein receptor, the Kupffer cell receptor, and the B-cell differentiation antigen Lyb-2 (CD72). It appears that within the C-type lectin superfamily, there is a subfamily of structurally related membrane-bound receptor proteins that contain alpha-helical coiled-coil stalks of various lengths.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-1195388, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-1698844, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-1826018, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2031185, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2137845, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2140512, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2141045, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2290831, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2300204, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2337572, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2438206, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2468089, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2529541, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2529542, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2532894, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2645579, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2661270, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2788165, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2797188, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2836387, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2877743, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2911757, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2949326, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2958779, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-2995379, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3034567, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3289117, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3290208, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3584121, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3597443, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-3818631, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-6319386, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-6341606, http://linkedlifedata.com/resource/pubmed/commentcorrection/1309956-880354
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation..., http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly, http://linkedlifedata.com/resource/pubmed/chemical/Asialoglycoprotein Receptor, http://linkedlifedata.com/resource/pubmed/chemical/CD72 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Lectins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Tropomyosin
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
753-7
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed-meshheading:1309956-Amino Acid Sequence, pubmed-meshheading:1309956-Animals, pubmed-meshheading:1309956-Antigens, CD, pubmed-meshheading:1309956-Antigens, Differentiation, B-Lymphocyte, pubmed-meshheading:1309956-Antigens, Ly, pubmed-meshheading:1309956-Asialoglycoprotein Receptor, pubmed-meshheading:1309956-Humans, pubmed-meshheading:1309956-Kupffer Cells, pubmed-meshheading:1309956-Lectins, pubmed-meshheading:1309956-Membrane Glycoproteins, pubmed-meshheading:1309956-Mice, pubmed-meshheading:1309956-Molecular Sequence Data, pubmed-meshheading:1309956-Protein Conformation, pubmed-meshheading:1309956-Rats, pubmed-meshheading:1309956-Receptors, Cell Surface, pubmed-meshheading:1309956-Receptors, Fc, pubmed-meshheading:1309956-Receptors, IgE, pubmed-meshheading:1309956-Receptors, Immunologic, pubmed-meshheading:1309956-Tropomyosin
pubmed:year
1992
pubmed:articleTitle
Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins.
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