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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6357
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pubmed:dateCreated |
1992-2-18
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pubmed:abstractText |
To test models of T-cell recognition, mice transgenic for T-cell receptor alpha or beta chain have been immunized with variant peptides that force changes in the resulting T-cell response. In particular, charge substitutions on the peptide often elicit reciprocal charges in the junctional (CDR3) sequences of T-cell receptor V alpha or V beta chains, indicating direct T-cell receptor-peptide contact, and allowing derivation of a topology for the T-cell receptor-MHC interaction. At one position on the peptide, variants transformed a homogeneous V beta response into a very heterogeneous one.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
224-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1309938-Amino Acid Sequence,
pubmed-meshheading:1309938-Animals,
pubmed-meshheading:1309938-Antigens, CD3,
pubmed-meshheading:1309938-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1309938-Base Sequence,
pubmed-meshheading:1309938-Binding, Competitive,
pubmed-meshheading:1309938-Columbidae,
pubmed-meshheading:1309938-Cytochrome c Group,
pubmed-meshheading:1309938-Genetic Variation,
pubmed-meshheading:1309938-Kinetics,
pubmed-meshheading:1309938-Lymph Nodes,
pubmed-meshheading:1309938-Lymphocyte Activation,
pubmed-meshheading:1309938-Lymphocytes,
pubmed-meshheading:1309938-Macromolecular Substances,
pubmed-meshheading:1309938-Major Histocompatibility Complex,
pubmed-meshheading:1309938-Mice,
pubmed-meshheading:1309938-Mice, Transgenic,
pubmed-meshheading:1309938-Models, Structural,
pubmed-meshheading:1309938-Molecular Sequence Data,
pubmed-meshheading:1309938-Moths,
pubmed-meshheading:1309938-Oligodeoxyribonucleotides,
pubmed-meshheading:1309938-Protein Conformation,
pubmed-meshheading:1309938-Receptors, Antigen, T-Cell
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pubmed:year |
1992
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pubmed:articleTitle |
Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.
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pubmed:affiliation |
Department of Microbiology and Immunology, Stanford University, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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