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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-9-30
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pubmed:abstractText |
In this study we examined erythropoiesis in the bone marrow and spleen of 9 to 12-day-old neonatal rats suckled by bleeding-induced anemic mothers. Quantitative evaluations of the spleen revealed a significant decrease in total numbers of nucleated RBC/mg spleen in 11-day-old pups nursed by the anemic mother which returned to control values by day 12. A significant reduction in total numbers of nucleated RBC/mg marrow was seen in both 11 and 12-day-old pups of anemic mothers when compared to control values. These results suggest that: 1. Ep is transmitted to suckling rats via the maternal milk; 2. Ep in the neonate exerts its influence predominantly at the level of the differentiated erythroid compartment probably by causing a shortening of the mean transit time of the proliferating erythroblast compartment and/or by decrease in the maturation time of the nonproliferating orthochromatic and reticulocyte compartments; 3. the regulation of erythropoiesis in the neonate differs from that in the adult.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1210-0668
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1308157-Anemia,
pubmed-meshheading:1308157-Animals,
pubmed-meshheading:1308157-Animals, Newborn,
pubmed-meshheading:1308157-Bone Marrow Cells,
pubmed-meshheading:1308157-Erythrocyte Count,
pubmed-meshheading:1308157-Erythropoiesis,
pubmed-meshheading:1308157-Erythropoietin,
pubmed-meshheading:1308157-Female,
pubmed-meshheading:1308157-Hemorrhage,
pubmed-meshheading:1308157-Maternal-Fetal Exchange,
pubmed-meshheading:1308157-Milk,
pubmed-meshheading:1308157-Pregnancy,
pubmed-meshheading:1308157-Rats,
pubmed-meshheading:1308157-Spleen
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pubmed:year |
1992
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pubmed:articleTitle |
Neonatal erythropoiesis. II. Bone marrow and splenic erythropoietic activity: data suggest erythropoietin transfer via maternal milk.
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pubmed:affiliation |
Department of Biology, Morgan State University, Baltimore, Maryland 21239.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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