Linked Life Data

1308075

Source:http://linkedlifedata.com/resource/pubmed/id/1308075

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-9-23
pubmed:abstractText
To assess the value of alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) in the diagnosis of painful crisis (PC) of sickle cell anaemia (SCA), we studied plasma enzyme levels in 55 children with HbSS and 21 control subjects with haemoglobin genotype AA. In 21 children with SCA, mean plasma alpha-HBDH was 373.8 +/- 113.5 micrograms/l during PC and during steady state in 34 children, it was 341.2 +/- 103.4 micrograms/l. These values were significantly higher than that of 128 +/- 19.5 micrograms/l obtained in control subjects. However, the difference between mean plasma alpha-HBDH levels in SCA children in PC and in steady state was 32.6 micrograms/l, t = 1.095; P < 0.2. There was no correlation between alpha-HBDH levels and reticulocyte counts (r = 0.0856; t = 0.4565; 0.7 < P < 0.6). The high levels of alpha-HBDH in patients with SCA is probably due to chronic haemolysis and not marrow infarction. Therefore, alpha-HBDH is of doubtful value in the diagnosis of painful crisis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0309-3913
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia.
pubmed:affiliation
Institute of Child Health College of Medical Sciences, University of Benin.
pubmed:publicationType
Journal Article