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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1992-11-13
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pubmed:abstractText |
The homologous C-terminal repeats of Clostridium difficile toxins (ToxA and ToxB) and streptococcal glucosyltransferases appear to mediate protein-carbohydrate interactions at cellular binding sites with sugar moieties as substrates. A consensus sequence of 134 repeating units from gram-positive bacteria indicates that these repeats have a modular design with (i) a stretch of aromatic amino acids proposed to be involved in the primary carbohydrate-protein interaction, (ii) an amplification of this interaction by repetition of the respective sequences, and (iii) a second domain, not characterized, that is responsible for carbohydrate specificity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-1603068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-1670930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-1715320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-1741035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-1827439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2142479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2148295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2150658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2231724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2307516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2461836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2875013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-2976010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3040685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3040686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3058393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3144429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3422470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1307487-3540569
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6707-10
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1307487-Amino Acid Sequence,
pubmed-meshheading:1307487-Bacterial Proteins,
pubmed-meshheading:1307487-Bacterial Toxins,
pubmed-meshheading:1307487-Binding Sites,
pubmed-meshheading:1307487-Carbohydrate Metabolism,
pubmed-meshheading:1307487-Clostridium difficile,
pubmed-meshheading:1307487-Consensus Sequence,
pubmed-meshheading:1307487-Cytotoxins,
pubmed-meshheading:1307487-Enterotoxins,
pubmed-meshheading:1307487-Glucosyltransferases,
pubmed-meshheading:1307487-Molecular Sequence Data,
pubmed-meshheading:1307487-Sequence Homology, Amino Acid,
pubmed-meshheading:1307487-Streptococcus mutans
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pubmed:year |
1992
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pubmed:articleTitle |
Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases.
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pubmed:affiliation |
Institut für Medizinische Mikrobiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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