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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-7-19
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pubmed:abstractText |
Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0869-2092
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1305426-Animals,
pubmed-meshheading:1305426-Behavior, Animal,
pubmed-meshheading:1305426-Brain,
pubmed-meshheading:1305426-Brain Chemistry,
pubmed-meshheading:1305426-Central Nervous System Diseases,
pubmed-meshheading:1305426-Drug Evaluation, Preclinical,
pubmed-meshheading:1305426-Ethanol,
pubmed-meshheading:1305426-Female,
pubmed-meshheading:1305426-Glutamates,
pubmed-meshheading:1305426-Higher Nervous Activity,
pubmed-meshheading:1305426-Male,
pubmed-meshheading:1305426-Nicotinic Acids,
pubmed-meshheading:1305426-Pregnancy,
pubmed-meshheading:1305426-Prenatal Exposure Delayed Effects,
pubmed-meshheading:1305426-Psychotropic Drugs,
pubmed-meshheading:1305426-Rats
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pubmed:articleTitle |
[The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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