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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5-6
|
pubmed:dateCreated |
1993-7-1
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pubmed:abstractText |
The aetiopathogenesis of adult renal tumors is poorly understood. The specific chromosomal changes detected by the study of tumor karyotypes suggest a cascade of oncogene activation and tumor suppressor gene inactivation in the course of renal carcinogenesis. These cytogenetic studies have isolated two entities: non-papillary carcinomas (clear cell and/or eosinophil carcinomas) and tubulopapillary tumors (cortical adenoma, basophil papillary carcinoma). Specific changes of the short arm of chromosome 3 are observed in 70 to 85% of cases of clear cell carcinomas, while trisomy 17 is detected in 70% of cases of tubulopapillary tumors. Cytogenetics is also able to distinguish low and high grade malignant tubulopapillary carcinomas. Limited data are available at the present time concerning oncocytomas.
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
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pubmed:issn |
0395-501X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
40
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
301-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1304117-Adenoma,
pubmed-meshheading:1304117-Adult,
pubmed-meshheading:1304117-Carcinoma,
pubmed-meshheading:1304117-Chromosome Aberrations,
pubmed-meshheading:1304117-Chromosome Disorders,
pubmed-meshheading:1304117-Chromosomes, Human, Pair 14,
pubmed-meshheading:1304117-Chromosomes, Human, Pair 17,
pubmed-meshheading:1304117-Chromosomes, Human, Pair 3,
pubmed-meshheading:1304117-Chromosomes, Human, Pair 5,
pubmed-meshheading:1304117-Chromosomes, Human, Pair 7,
pubmed-meshheading:1304117-Genes, Tumor Suppressor,
pubmed-meshheading:1304117-Humans,
pubmed-meshheading:1304117-Kidney Neoplasms,
pubmed-meshheading:1304117-Oncogenes,
pubmed-meshheading:1304117-Trisomy
|
pubmed:year |
1992
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pubmed:articleTitle |
[Genetic aspects of renal tumors in adults].
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pubmed:affiliation |
INSERM Unité 73, Paris.
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pubmed:publicationType |
Journal Article,
English Abstract,
Review,
Research Support, Non-U.S. Gov't
|