|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3-4
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|
pubmed:dateCreated |
1993-6-30
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|
pubmed:abstractText |
Apocynin (4-hydroxy-3-methoxy-acetophenone) is a potent and selective inhibitor of neutrophil oxyradical production. The mechanism of action involves metabolic activation in a (myelo)-peroxidase-dependent reaction. The reaction product(s) prevent(s) the assembly of the superoxide anion-generating NADPH:O2 oxidoreductase by conjugation to essential thiol groups. Different neutrophil functions that are essential to their bactericidal activity, however, remain intact. When administered orally a potent anti-inflammatory activity was found in rats with experimentally induced local or systemic inflammation.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0898-2848
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
119-35
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1303726-Acetophenones,
pubmed-meshheading:1303726-Animals,
pubmed-meshheading:1303726-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:1303726-Biotransformation,
pubmed-meshheading:1303726-Male,
pubmed-meshheading:1303726-Neutrophils,
pubmed-meshheading:1303726-Phenols,
pubmed-meshheading:1303726-Quinones,
pubmed-meshheading:1303726-Rats,
pubmed-meshheading:1303726-Respiratory Burst
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug.
|
|
pubmed:affiliation |
Department of Chronic Diseases, ITRI-TNO, Rijswijk, The Netherlands.
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Review
|
