Linked Life Data

1303663

Source:http://linkedlifedata.com/resource/pubmed/id/1303663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-6-29
pubmed:abstractText
Anisodamine is commonly used in clinic as vasodilator. In the present study, the effects of anisodamine on cochlear blood flow were investigated in living guinea pigs using intravital microscopic techniques. The results showed that intravenous infusion of anisodamine (10mg/kg, 5mg/kg, 2 mg/kg) produced a dose dependent reduction in blood pressure. Large dose (10mg/kg) caused significant decrease in blood flow rate to 68.7 +/- 7.4% of the control value with no significant change in vessel diameter. On the other hand, medium and small doses (5mg/kg, 2mg/kg), which produced relatively smaller reduction in blood pressure caused no significant alternation in blood flow rate and vessel diameter. Also, when intramuscular, infusion of anisodamine (2mg/kg) was used no significant difference in blood flow rate, vessel diameter as well as blood pressure were found. The results indicated that increase in cochlear blood supply can not be induced by anisodamine in normal guinea pigs.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0412-3948
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-7, 381
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Effect of anisodamine on cochlear blood flow in living guinea pigs].
pubmed:affiliation
Chinese PLA General Hospital, Beijing.
pubmed:publicationType
Journal Article, English Abstract