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pubmed-article:1301355pubmed:abstractTextFelodipine, a vasoselective dihydropyridine calcium antagonist, has been given i.v. (0.2 mumol/kg) to anaesthetized and conscious male rats. There was no effect of pentobarbital anaesthesia on bile flow over a 6 h observation period. Felodipine increased the 6 h recovery of bile by approximately 25% in the conscious rat but in the anaesthetized rat there was a 20% decrease in bile flow following i.v. felodipine. A positive effect of Na-taurocholate infusion (1 mumol/min/100 g body weight) on bile flow in conscious rats was reinforced by concomitant felodipine dosing. Accumulated 6 h recoveries were 2.32 +/- 0.80 g/100 g body weight (control), 3.09 +/- 0.91 g/100 g body weight (taurocholate) and 5.00 +/- 0.80 g/100 g body weight. (taurocholate plus felodipine). The excretion of felodipine in the bile was significantly reduced during anaesthesia and during infusion of 2% bovine serum albumin (0.01 ml/min/100 g body weight) to conscious rats.lld:pubmed
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pubmed-article:1301355pubmed:authorpubmed-author:RegårdhC GCGlld:pubmed
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pubmed-article:1301355pubmed:authorpubmed-author:WangS XSXlld:pubmed
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pubmed-article:1301355pubmed:dateRevised2011-2-2lld:pubmed
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pubmed-article:1301355pubmed:articleTitleThe effect of felodipine on bile flow in pentobarbital anaesthetized rats and conscious rats receiving bile salt supplementation.lld:pubmed
pubmed-article:1301355pubmed:affiliationAstra Hässle AB, Mölndal, Sweden.lld:pubmed
pubmed-article:1301355pubmed:publicationTypeJournal Articlelld:pubmed