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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1993-6-1
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pubmed:abstractText |
Felodipine, a vasoselective dihydropyridine calcium antagonist, has been given i.v. (0.2 mumol/kg) to anaesthetized and conscious male rats. There was no effect of pentobarbital anaesthesia on bile flow over a 6 h observation period. Felodipine increased the 6 h recovery of bile by approximately 25% in the conscious rat but in the anaesthetized rat there was a 20% decrease in bile flow following i.v. felodipine. A positive effect of Na-taurocholate infusion (1 mumol/min/100 g body weight) on bile flow in conscious rats was reinforced by concomitant felodipine dosing. Accumulated 6 h recoveries were 2.32 +/- 0.80 g/100 g body weight (control), 3.09 +/- 0.91 g/100 g body weight (taurocholate) and 5.00 +/- 0.80 g/100 g body weight. (taurocholate plus felodipine). The excretion of felodipine in the bile was significantly reduced during anaesthesia and during infusion of 2% bovine serum albumin (0.01 ml/min/100 g body weight) to conscious rats.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0378-7966
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-8
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pubmed:dateRevised |
2011-2-2
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pubmed:meshHeading |
pubmed-meshheading:1301355-Anesthesia,
pubmed-meshheading:1301355-Animals,
pubmed-meshheading:1301355-Bile,
pubmed-meshheading:1301355-Bile Acids and Salts,
pubmed-meshheading:1301355-Felodipine,
pubmed-meshheading:1301355-Male,
pubmed-meshheading:1301355-Pentobarbital,
pubmed-meshheading:1301355-Rats,
pubmed-meshheading:1301355-Rats, Sprague-Dawley,
pubmed-meshheading:1301355-Taurocholic Acid
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pubmed:articleTitle |
The effect of felodipine on bile flow in pentobarbital anaesthetized rats and conscious rats receiving bile salt supplementation.
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pubmed:affiliation |
Astra Hässle AB, Mölndal, Sweden.
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pubmed:publicationType |
Journal Article
|