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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-5-27
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pubmed:abstractText |
The anticarcinogenic properties of epsilon-aminocaproic acid were studied in two rat models of carcinogenesis. Esophageal tumors were induced by oral instillations of a total dose of 54 mg/kg body weight N-methyl-N-benzylnitrosamine whereas tumors of the nervous system and kidney-by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. epsilon-Aminocaproic acid given at a concentration of 1 milligram drinking water at the post-initiation stage of the carcinogenesis was shown to inhibit the induction of cancer and papilloma of the esophagus, brain glioma, peripheral nerve neurinoma and mesenchymal tumors of the kidney.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0507-3758
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1300690-6-Aminocaproic Acid,
pubmed-meshheading:1300690-Animals,
pubmed-meshheading:1300690-Anticarcinogenic Agents,
pubmed-meshheading:1300690-Carcinogens,
pubmed-meshheading:1300690-Chi-Square Distribution,
pubmed-meshheading:1300690-Dimethylnitrosamine,
pubmed-meshheading:1300690-Drug Screening Assays, Antitumor,
pubmed-meshheading:1300690-Esophageal Neoplasms,
pubmed-meshheading:1300690-Ethylnitrosourea,
pubmed-meshheading:1300690-Female,
pubmed-meshheading:1300690-Incidence,
pubmed-meshheading:1300690-Kidney Neoplasms,
pubmed-meshheading:1300690-Male,
pubmed-meshheading:1300690-Nervous System Neoplasms,
pubmed-meshheading:1300690-Pregnancy,
pubmed-meshheading:1300690-Prenatal Exposure Delayed Effects,
pubmed-meshheading:1300690-Rats
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pubmed:year |
1992
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pubmed:articleTitle |
[The inhibiting effect of epsilon-aminocaproic acid on the incidence of induced tumors of the esophagus, nervous system and kidneys].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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