Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1976-4-15
|
pubmed:abstractText |
Five patients with aplastic anemia were shown to be sensitized in vivo to the transplantation antigens of HL-A identical and MLC nonreactive sibling bone marrow transplantation donors. The sensitization in four cases were detected by antibody-dependent cell-mediated lysis (AICML) techniques, and in one case by antibody-dependent cell-mediated lysis (ADCML). In two cases the inherited nature of the sensitizing antigen was demonstrated, and in one case the inheritance of the antigen was shown by a family study to be independent of the HL-A and MLC loci. Maximal AICML was demonstrated in two cases at the time of bone marrow graft rejection. Successful transplants after immunosuppression with rabbit anti-thymocyte serum, procarbazine, and cyclophosphamide were performed in two patients, in whom sensitization was detected before transplantation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0041-1337
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
110-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:129895-Antibody Specificity,
pubmed-meshheading:129895-Bone Marrow Cells,
pubmed-meshheading:129895-Bone Marrow Transplantation,
pubmed-meshheading:129895-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:129895-Female,
pubmed-meshheading:129895-Genotype,
pubmed-meshheading:129895-Graft Rejection,
pubmed-meshheading:129895-HLA Antigens,
pubmed-meshheading:129895-Histocompatibility Antigens,
pubmed-meshheading:129895-Humans,
pubmed-meshheading:129895-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:129895-Male,
pubmed-meshheading:129895-Transplantation, Homologous
|
pubmed:year |
1976
|
pubmed:articleTitle |
Detection of genetically determined histocompatibility antigen differences between HL-A identical and MLC nonreactive siblings.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|