Linked Life Data

1298542

Source:http://linkedlifedata.com/resource/pubmed/id/1298542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-5-13
pubmed:abstractText
In this report, using the radio-ligand binding assay with [3H]-dexamethasone (Dex) as the ligand, we studied the changes in glucocorticoid receptor (GCR) in canine peripheral lymphocyte under unstressed condition and during the early postburn period (within 48 hours after burn). The results showed that the apparent binding capacity (Ro) and the apparent dissociation constant (Kd) of GCR were 8468 +/- 993 sites per cell and 10.2 +/- 0.6 nM (n = 6), respectively, under unstressed condition. The number of [3H]-Dex specific binding sites measured by the single saturated analysis (Rs) from 16 healthy mongrel dogs under unstressed condition was 4531 +/- 396 sites per cell. The Rs was decreased sharply at the second post-burn hour, reaching the lowest level of 2501 +/- 460 sites per cell. But it recovered to 78.9% of the level measured in unstressed condition. There was significant negative relationship between the plasma cortisol concentration and GCR levels of lymphocyte. The results suggest that the changes in GCR in postburn period may be related to the down-regulation of GCR by Gc; that GCR may be of very important significance in the pathophysiologic changes after burn injury.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1000-7806
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-7, 250
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Glucocorticoid receptor (GCR) in canine peripheral lymphocyte during early postburn period].
pubmed:affiliation
Burn Department, Nan Fang Hospital, First Military College, GuangZhou.
pubmed:publicationType
Journal Article, English Abstract