pubmed-article:1298399 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0001044 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0439852 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0184967 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0004916 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C1709845 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0055571 | lld:lifeskim |
pubmed-article:1298399 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
pubmed-article:1298399 | pubmed:issue | 10-12 | lld:pubmed |
pubmed-article:1298399 | pubmed:dateCreated | 1993-5-7 | lld:pubmed |
pubmed-article:1298399 | pubmed:abstractText | The inhibiting compounds were separated by micro-column liquid chromatography in the mobile phase containing the natural substrate acetylcholine. A home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ACHE) in human red blood cell membrane and choline oxidase (CHO) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. The inhibition effect of the solutes caused a decrease in the acetylcholinesterase activity, a decrease in the formation of hydrogen peroxide and also a decrease in the response corresponding to the concentration of the solutes. The rate of the enzyme regeneration was also recorded. The micro-system was compared with a conventional LC system comprising commercially prepared enzyme reactor. The stability of the enzymes is at least 3 weeks at ambient temperature. The limit of detection depends on biological activity of inhibition and for galanthamine was 1 pmol. | lld:pubmed |
pubmed-article:1298399 | pubmed:language | eng | lld:pubmed |
pubmed-article:1298399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1298399 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1298399 | pubmed:issn | 0731-7085 | lld:pubmed |
pubmed-article:1298399 | pubmed:author | pubmed-author:RemienJJ | lld:pubmed |
pubmed-article:1298399 | pubmed:author | pubmed-author:SalamounJJ | lld:pubmed |
pubmed-article:1298399 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1298399 | pubmed:volume | 10 | lld:pubmed |
pubmed-article:1298399 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1298399 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1298399 | pubmed:pagination | 931-6 | lld:pubmed |
pubmed-article:1298399 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:1298399 | pubmed:articleTitle | Indirect detection of anti-acetylcholinesterase compounds in microcolumn liquid chromatography using packed bed reactor with immobilized human red blood cell acetylcholinesterase and choline oxidase. | lld:pubmed |
pubmed-article:1298399 | pubmed:affiliation | Walther-Straub Institute of Pharmacology and Toxicology, Munich, Germany. | lld:pubmed |
pubmed-article:1298399 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1298399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |