|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
1993-4-30
|
|
pubmed:abstractText |
1. The stellate cell-mediated inhibition of Purkinje cells was studied by intracellular recordings in an in vitro slice preparation of the turtle cerebellar cortex. A graded inhibitory postsynaptic potential (IPSP) was recorded in Purkinje cells upon stimulation of the parallel fibre-stellate cell pathway. 2. The IPSP was abolished by bicuculline, and had a reversal potential around -75 mV, consistent with a GABAA receptor-operated Cl- conductance dominating the response investigated here. 3. Paired recordings from synaptically coupled stellate cells and Purkinje cells demonstrated that the inhibitory input from a single stellate cell is sufficient to reduce the firing in a Purkinje cell. 4. The extracellular-evoked IPSP interacted with the active postsynaptic membrane properties in the Purkinje cell. Interaction with both the Na+ plateau and the IA prolonged the responses to an IPSP, making the net effect of the inhibitory response dependent on the membrane potential in each postsynaptic neurone. 5. A precisely timed IPSP was particularly efficient in reducing dendritic Ca2+ influx. 6. The voltage-dependent Ca2+ component of a climbing fibre response (CFR) as well as of a parallel fibre (PF) input was reduced by the IPSP. 7. It is suggested that Ca2+ spike-mediated reduction in Purkinje cell excitability may be prevented by the stellate cell IPSP-mediated reduction in Ca2+ influx.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-1338460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-205321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2268180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2464409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2466989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2472067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2585287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2585289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-2899909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-3066636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-3177894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-3199192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-3701658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-4329778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-4333656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-5647436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-5808006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-5943696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-7441552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1297838-7441554
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-3751
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
457
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
355-67
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Stellate cell inhibition of Purkinje cells in the turtle cerebellum in vitro.
|
|
pubmed:affiliation |
Institute of Neurophysiology, University of Copenhagen, Denmark.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
