Source:http://linkedlifedata.com/resource/pubmed/id/12975667
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-9-16
|
| pubmed:abstractText |
120 chemotherapy naive patients were treated with gemcitabine 1250 mg/m2 iv. days 1 and 8 and cisplatin 70 mg/m2 iv. on day 1 between May 1999 and June 2001. The treatments were administered in 21 cycles. The median age of the patients was 53.1 years, the male/female ratio 65%-35%. Performance status was: WHO 0: 26%, WHO 1: 74%. The staging of patients were: IIIA-N2 23%, IIIB 37%, IV 40%. By histology the tumors were: 53.3% adenocarcinoma, 40% squamous cell carcinoma, 2.5% adenosquamous carcinoma, 0.8% macrocellular carcinoma and 3% non-small cell carcinoma (not categorised). We evaluated 413 cycles of chemotherapy. The median number of cycles was 3.44. The primary endpoint of the study was the median survival and time to progression, and the response rate. The results are the following: RR 40% (PR 37.5%, CR 2.5%), MR 13.3%, SD 25%, PD 22%. The time to progression (TTP) in the SD+MR group: 29.8 weeks, in the RR group: 34.1 weeks, mean of all patients: 28.1 weeks. The survival time was estimated by Kaplan-Meier curves. The median survival (MS) of all treated patients was: 54.9 weeks, in the PD group: 34.4 weeks, in the SD+MR group: 59.1 weeks, in the PR+CR group: 62.1 weeks. Conclusion: gemcitabine and cisplatin combination is a very well tolerated therapeutic regimen in the 1st line treatment of NSCLC. Furthermore, this treatment improves the RR and the survival of the patients as well.
|
| pubmed:language |
hun
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0025-0244
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12975667-Adenocarcinoma,
pubmed-meshheading:12975667-Adult,
pubmed-meshheading:12975667-Aged,
pubmed-meshheading:12975667-Antimetabolites, Antineoplastic,
pubmed-meshheading:12975667-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12975667-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12975667-Carcinoma, Squamous Cell,
pubmed-meshheading:12975667-Cisplatin,
pubmed-meshheading:12975667-Deoxycytidine,
pubmed-meshheading:12975667-Drug Administration Schedule,
pubmed-meshheading:12975667-Female,
pubmed-meshheading:12975667-Humans,
pubmed-meshheading:12975667-Lung Neoplasms,
pubmed-meshheading:12975667-Male,
pubmed-meshheading:12975667-Middle Aged,
pubmed-meshheading:12975667-Neoplasm Staging,
pubmed-meshheading:12975667-Odds Ratio,
pubmed-meshheading:12975667-Survival Analysis,
pubmed-meshheading:12975667-Treatment Outcome
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
[Effectiveness of Gemzar-Cisplatin therapy in stage IIIA-N2, IIIB and IV non-small cell lung cancer].
|
| pubmed:affiliation |
Országos Korányi TBC és Pulmonológiai Intézet, Budapest 1529, Hungary. ostorosgyula@freemail.hu
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract
|