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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-9-12
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pubmed:abstractText |
Hepatic cytochrome P450 isoenzymes constitute a superfamily of hemoproteins that play a major role in the metabolism of endogenous compounds and in the detoxification of xenobiotic molecules. P450 3A4 is one of the most important forms in human being, and mediates the metabolism of around 70 % of therapeutic drugs and endogenous compounds. Propofol, a widely used intravenous anesthetic drug, is known to inhibit cytochrome P450 activities in isolated rat hepatocytes. The goal of this study was to evaluate the potential efficacy of propofol on P450 3A4 in a dose-dependent manner to understand its drug-drug interaction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1007-9327
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1959-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12970884-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:12970884-Cells, Cultured,
pubmed-meshheading:12970884-Cytochrome P-450 CYP3A,
pubmed-meshheading:12970884-Dose-Response Relationship, Drug,
pubmed-meshheading:12970884-Enzyme Inhibitors,
pubmed-meshheading:12970884-Hepatocytes,
pubmed-meshheading:12970884-Humans,
pubmed-meshheading:12970884-Oxidoreductases, N-Demethylating,
pubmed-meshheading:12970884-Propofol
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pubmed:year |
2003
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pubmed:articleTitle |
Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes.
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pubmed:affiliation |
Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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