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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5639
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pubmed:dateCreated |
2003-9-12
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pubmed:abstractText |
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BleharskiJoshua RJR,
pubmed-author:BloomBarry RBR,
pubmed-author:BurdickAnneA,
pubmed-author:ColonnaMarcoM,
pubmed-author:EisenbergDavidD,
pubmed-author:GraeberThomas GTG,
pubmed-author:LiHuiyingH,
pubmed-author:MeinkenChristophC,
pubmed-author:ModlinRobert LRL,
pubmed-author:OchoaMaria-TeresaMT,
pubmed-author:RöllinghoffMartinM,
pubmed-author:ReaThomas HTH,
pubmed-author:SarnoEuzenir NEN,
pubmed-author:StengerSteffenS,
pubmed-author:WagnerManfredM,
pubmed-author:YamamuraMasahiroM
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12970564-Algorithms,
pubmed-meshheading:12970564-Cluster Analysis,
pubmed-meshheading:12970564-Colony Count, Microbial,
pubmed-meshheading:12970564-Cytokines,
pubmed-meshheading:12970564-Gene Expression Profiling,
pubmed-meshheading:12970564-Gene Expression Regulation,
pubmed-meshheading:12970564-Genes, Immunoglobulin,
pubmed-meshheading:12970564-Humans,
pubmed-meshheading:12970564-Immunity, Cellular,
pubmed-meshheading:12970564-Immunity, Innate,
pubmed-meshheading:12970564-Leprosy, Lepromatous,
pubmed-meshheading:12970564-Leprosy, Tuberculoid,
pubmed-meshheading:12970564-Macrophages, Alveolar,
pubmed-meshheading:12970564-Membrane Glycoproteins,
pubmed-meshheading:12970564-Mycobacterium tuberculosis,
pubmed-meshheading:12970564-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12970564-Polymerase Chain Reaction,
pubmed-meshheading:12970564-Principal Component Analysis,
pubmed-meshheading:12970564-Receptors, Cell Surface,
pubmed-meshheading:12970564-Receptors, Immunologic,
pubmed-meshheading:12970564-Toll-Like Receptors,
pubmed-meshheading:12970564-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
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pubmed:affiliation |
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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