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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-6
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pubmed:abstractText |
Increased expression of the low-density lipoprotein receptor (LDLR) is generally considered beneficial for reducing plasma cholesterol and atherosclerosis, and its downregulation has been thought to explain the association between apolipoprotein (apo) E4 and increased risk of coronary heart disease in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12969990-Animals,
pubmed-meshheading:12969990-Apolipoprotein E3,
pubmed-meshheading:12969990-Apolipoprotein E4,
pubmed-meshheading:12969990-Apolipoproteins E,
pubmed-meshheading:12969990-Arteriosclerosis,
pubmed-meshheading:12969990-Crosses, Genetic,
pubmed-meshheading:12969990-Diet, Atherogenic,
pubmed-meshheading:12969990-Dietary Fats,
pubmed-meshheading:12969990-Female,
pubmed-meshheading:12969990-Gene Expression,
pubmed-meshheading:12969990-Gene Targeting,
pubmed-meshheading:12969990-Humans,
pubmed-meshheading:12969990-Hypercholesterolemia,
pubmed-meshheading:12969990-Lipoproteins, VLDL,
pubmed-meshheading:12969990-Male,
pubmed-meshheading:12969990-Mice,
pubmed-meshheading:12969990-Mice, Inbred C57BL,
pubmed-meshheading:12969990-Receptors, LDL,
pubmed-meshheading:12969990-Recombinant Fusion Proteins,
pubmed-meshheading:12969990-Species Specificity,
pubmed-meshheading:12969990-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.
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pubmed:affiliation |
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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