Linked Life Data

12969752

Source:http://linkedlifedata.com/resource/pubmed/id/12969752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-9-12
pubmed:abstractText
The experiments showed that sequential drug discriminations can be learned and retained under a fixed-interval (FI) schedule for more than 18 months without additional training under a complex three-choice procedure. Pigeons were trained to discriminate among 5 mg/kg pentobarbital, 2 mg/kg D-amphetamine, and saline. After responding stabilized, dose-response curves were determined for other drugs. Subsequently, pentobarbital was replaced with 5 mg/kg morphine as a training drug, and D-amphetamine was replaced with 30 mg/kg caffeine. After the pigeons learned these new discriminations, dose-response curves were redetermined. Initially, chlordiazepoxide substituted for pentobarbital, cocaine substituted for D-amphetamine, and nicotine partially substituted for D-amphetamine. Morphine, Delta9-tetrahydrocannabinol, and caffeine did not substitute for either drug. After retraining with morphine and caffeine, responding occurred on the pentobarbital/morphine key after pentobarbital, chlordiazepoxide and morphine and on the D-amphetamine/caffeine key after D-amphetamine, cocaine and caffeine. After nicotine and Delta9-tetrahyrdocannabinol, responding occurred on the saline key. These data show that drug discriminations learned under fixed-interval schedules are retained for long time periods, even when discrimination training with other drugs occurs during the retention period.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
476
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12969752-Animals, pubmed-meshheading:12969752-Behavior, Animal, pubmed-meshheading:12969752-Caffeine, pubmed-meshheading:12969752-Central Nervous System Depressants, pubmed-meshheading:12969752-Central Nervous System Stimulants, pubmed-meshheading:12969752-Chlordiazepoxide, pubmed-meshheading:12969752-Cocaine, pubmed-meshheading:12969752-Columbidae, pubmed-meshheading:12969752-Dextroamphetamine, pubmed-meshheading:12969752-Discrimination Learning, pubmed-meshheading:12969752-Dose-Response Relationship, Drug, pubmed-meshheading:12969752-Generalization (Psychology), pubmed-meshheading:12969752-Male, pubmed-meshheading:12969752-Morphine, pubmed-meshheading:12969752-Nicotine, pubmed-meshheading:12969752-Pentobarbital, pubmed-meshheading:12969752-Reinforcement Schedule, pubmed-meshheading:12969752-Tetrahydrocannabinol
pubmed:year
2003
pubmed:articleTitle
Retention of sequential drug discriminations under fixed-interval schedules for long time periods without training.
pubmed:affiliation
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.