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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
9
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pubmed:dateCreated |
2003-9-12
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|
pubmed:abstractText |
The ubiquitin-proteosome pathway is important for selective degradation of short-lived protein in eukaryotic cells. In this pathway Skp2 (S-phase kinase-associated protein 2) plays a critical role in degrading cyclin-dependent kinase inhibitor p27. It is verified that Skp2 is an oncoprotein that promotes cell cycle progression in solid tumor, but its role in leukemia cells remains unclear. This study was designed to investigate the effect of Skp2 antisense oligodeoxynucleotides(ASODN) on the growth and proliferation of leukemic K562 cells and its probable mechanism.
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pubmed:language |
chi
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
|
pubmed:issn |
1000-467X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
948-53
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pubmed:dateRevised |
2010-7-28
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pubmed:meshHeading |
pubmed-meshheading:12969527-Cell Cycle,
pubmed-meshheading:12969527-Cell Cycle Proteins,
pubmed-meshheading:12969527-Cell Division,
pubmed-meshheading:12969527-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:12969527-Humans,
pubmed-meshheading:12969527-K562 Cells,
pubmed-meshheading:12969527-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:12969527-RNA, Messenger,
pubmed-meshheading:12969527-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:12969527-Tumor Suppressor Proteins
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pubmed:year |
2003
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|
pubmed:articleTitle |
[Effect of Skp2 antisense oligodeoxynucleotide on growth and proliferation of K562 cells].
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pubmed:affiliation |
Department of Clinical Hematology, Chongqing University of Medical Sciences, Chongqing, 400016, PR China.
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pubmed:publicationType |
Journal Article,
English Abstract
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