Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-9-10
pubmed:abstractText
The purpose of this study is to investigate the clinical and histopathologic significance of hypoxia-inducible-factor 1alpha (HIF-1alpha) expression in oesophageal squamous cell carcinoma. One hundred and thirty surgically resected specimens of OSCC were immunohistochemically assessed for HIF-1alpha expression with monoclonal antibody. High HIF-1alpha immunostaining was detected in 40 specimens. The percentage of high HIF-1alpha expression cases increased with tumour stage according to pTNM system. High HIF-1alpha expression correlated with pTNM stage, depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion and positive surgical margin. The overall survival rate was worse in patients with high HIF-1alpha pattern than in patients with low-expression pattern. Univariate analyses identified high HIF-1alpha positivity, depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion, and a positive surgical margin as risk factors. Multivariate analyses indicated that depth of tumour invasion, lymph node metastasis and positive surgical margin, but not HIF-1alpha, were independent prognostic factors. Survival in patients with a high HIF-1alpha expression was significantly worse than in those with low expression in patient treated with adjuvant therapy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10091725, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10098401, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10353251, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10582706, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10660757, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10679484, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10903602, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10945599, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-10964323, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-11280732, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-11283857, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-11306467, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-11420480, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-11744734, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-3360652, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8438086, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8605557, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8627996, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8702901, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8756616, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-8961365, http://linkedlifedata.com/resource/pubmed/commentcorrection/12966423-9783886
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1042-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:12966423-Adult, pubmed-meshheading:12966423-Aged, pubmed-meshheading:12966423-Aged, 80 and over, pubmed-meshheading:12966423-Antigens, Neoplasm, pubmed-meshheading:12966423-Carcinoma, Squamous Cell, pubmed-meshheading:12966423-Esophageal Neoplasms, pubmed-meshheading:12966423-Female, pubmed-meshheading:12966423-Gene Expression Regulation, Neoplastic, pubmed-meshheading:12966423-Humans, pubmed-meshheading:12966423-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:12966423-Immunoenzyme Techniques, pubmed-meshheading:12966423-Lymph Nodes, pubmed-meshheading:12966423-Lymphatic Metastasis, pubmed-meshheading:12966423-Male, pubmed-meshheading:12966423-Middle Aged, pubmed-meshheading:12966423-Neoplasm Invasiveness, pubmed-meshheading:12966423-Neoplasm Staging, pubmed-meshheading:12966423-Prognosis, pubmed-meshheading:12966423-Survival Rate, pubmed-meshheading:12966423-Transcription Factors, pubmed-meshheading:12966423-Tumor Markers, Biological
pubmed:year
2003
pubmed:articleTitle
Overexpression of hypoxia-inducible-factor 1alpha(HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage.
pubmed:affiliation
Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. t-kuro@med.hokudai.ac.jp
pubmed:publicationType
Journal Article, Comparative Study