Source:http://linkedlifedata.com/resource/pubmed/id/12965188
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2003-9-10
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pubmed:abstractText |
The effects of in vitro exposure of human erythrocytes to different concentrations of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) were studied. The activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the level of reduced glutathione (GSH) were determined. The activity of erythrocyte superoxide dismutase SOD decreased with increasing dose of 2,4-D and 2,4-DCP, while glutathione peroxidase activity increased. 2,4-D (500 ppm) decreased the level of reduced glutathione in erythrocytes by 18% and 2,4-DCP (250 ppm) by 32%, respectively, in comparison with the controls. These results lead to the conclusion that in vitro administration of herbicide-2,4-D and its metabolite 2,4-DCP causes a decrease in the level of reduced glutathione in erythrocytes and significant changes in antioxidant enzyme activities. Comparison of the toxicity of 2,4-D and 2,4-DCP revealed that the most prominent changes occurred in human erythrocytes incubated with 2,4-DCP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4-Dichlorophenoxyacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/2,4-dichlorophenol,
http://linkedlifedata.com/resource/pubmed/chemical/Anthelmintics,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Herbicides,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1532-0456
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
435-41
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12965188-2,4-Dichlorophenoxyacetic Acid,
pubmed-meshheading:12965188-Anthelmintics,
pubmed-meshheading:12965188-Chlorophenols,
pubmed-meshheading:12965188-Erythrocytes,
pubmed-meshheading:12965188-Glutathione,
pubmed-meshheading:12965188-Glutathione Peroxidase,
pubmed-meshheading:12965188-Herbicides,
pubmed-meshheading:12965188-Humans,
pubmed-meshheading:12965188-Superoxide Dismutase
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pubmed:year |
2003
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pubmed:articleTitle |
Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes.
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pubmed:affiliation |
Department of Biophysics of Environmental Pollution, University of Lódz, Banacha 12/16, 90-237 Lódz, Poland. bukow@biol.uni.lodz.pl
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pubmed:publicationType |
Journal Article
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