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rdf:type |
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0017337,
umls-concept:C0021655,
umls-concept:C0205164,
umls-concept:C0332120,
umls-concept:C0332183,
umls-concept:C0332197,
umls-concept:C0332281,
umls-concept:C0752046,
umls-concept:C0963992,
umls-concept:C1280500,
umls-concept:C1556094,
umls-concept:C1852091
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pubmed:issue |
3
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pubmed:dateCreated |
2003-9-10
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pubmed:abstractText |
Resistin, specifically secreted from adipocytes, antagonizes insulin and represents a promising candidate gene for type 2 diabetes. We reported that a frequent single nucleotide polymorphism (SNP) +299G>A in this gene is not associated with type 2 diabetes. To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro. The 99 type 2 diabetic and 99 control subjects were typed by PCR direct sequencing or PCR-RFLP. No differences in frequencies of obesity, hyperlipidemia and hypertension were found between the type 2 diabetic subjects with G/G and those with G/A or A/A genotypes of the resistin SNP. When the combination of the resistin SNP with each of b3AR, PDE3B and LAL SNPs was assessed, no association with type 2 diabetes was evident. Therefore, the frequent SNP +299G>A in the resistin gene is unlikely to have major effects on susceptibility to insulin resistance syndrome associated with type 2 diabetes in Japanese subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0168-8227
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pubmed:author |
pubmed-author:FujiiYasuhisaY,
pubmed-author:KatoKenichiK,
pubmed-author:MakinoHideichiH,
pubmed-author:MurakamiAkikoA,
pubmed-author:MuraseMitsuharuM,
pubmed-author:NishimiyaTatsuyaT,
pubmed-author:OchiMasaakiM,
pubmed-author:OhashiJunJ,
pubmed-author:OnumaHiroshiH,
pubmed-author:OsawaHaruhikoH,
pubmed-author:ShimadaFumioF,
pubmed-author:ShimizuIkkiI,
pubmed-author:ShishinoKojiK
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12965109-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:12965109-Adult,
pubmed-meshheading:12965109-Aged,
pubmed-meshheading:12965109-Cyclic Nucleotide Phosphodiesterases, Type 3,
pubmed-meshheading:12965109-Diabetes Mellitus,
pubmed-meshheading:12965109-Diabetes Mellitus, Type 2,
pubmed-meshheading:12965109-Female,
pubmed-meshheading:12965109-Gene Frequency,
pubmed-meshheading:12965109-Genetic Predisposition to Disease,
pubmed-meshheading:12965109-Hormones, Ectopic,
pubmed-meshheading:12965109-Humans,
pubmed-meshheading:12965109-Hypertension,
pubmed-meshheading:12965109-Insulin Resistance,
pubmed-meshheading:12965109-Japan,
pubmed-meshheading:12965109-Male,
pubmed-meshheading:12965109-Middle Aged,
pubmed-meshheading:12965109-Obesity,
pubmed-meshheading:12965109-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12965109-Polymorphism, Single Nucleotide,
pubmed-meshheading:12965109-Resistin
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pubmed:year |
2003
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pubmed:articleTitle |
The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes.
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pubmed:affiliation |
Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, 791-0295 Ehime, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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