|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2003-10-28
|
|
pubmed:abstractText |
We have recently shown that genetic inactivation of phosphoinositide 3-kinase gamma (PI3Kgamma), the isoform linked to G-protein-coupled receptors, results in increased cardiac contractility with no effect on basal cell size. Signaling via the G-protein-coupled beta-adrenergic receptors has been implicated in cardiac hypertrophy and heart failure, suggesting that PI3Kgamma might play a role in the pathogenesis of heart disease.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
pubmed-author:BackxPeter HPH,
pubmed-author:CrackowerMichael AMA,
pubmed-author:ErikssonUrsU,
pubmed-author:GidrewiczDominicaD,
pubmed-author:Irie-SasakiJunkoJ,
pubmed-author:KozieradzkiIvonaI,
pubmed-author:OuditGavin YGY,
pubmed-author:PenningerJosef MJM,
pubmed-author:RybinVitalyi OVO,
pubmed-author:SaraoRenuR,
pubmed-author:SasakiTakehikoT,
pubmed-author:SteinbergSusan FSF,
pubmed-author:WadaTeijiT
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
28
|
|
pubmed:volume |
108
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2147-52
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12963636-Adrenergic beta-Agonists,
pubmed-meshheading:12963636-Animals,
pubmed-meshheading:12963636-Cardiomegaly,
pubmed-meshheading:12963636-Catalytic Domain,
pubmed-meshheading:12963636-Disease Models, Animal,
pubmed-meshheading:12963636-Fibrosis,
pubmed-meshheading:12963636-Heart,
pubmed-meshheading:12963636-Heart Failure,
pubmed-meshheading:12963636-Isoproterenol,
pubmed-meshheading:12963636-Male,
pubmed-meshheading:12963636-Mice,
pubmed-meshheading:12963636-Mice, Knockout,
pubmed-meshheading:12963636-Myocardium,
pubmed-meshheading:12963636-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:12963636-Signal Transduction
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
|
|
pubmed:affiliation |
Department of Physiology, University Health Network, University of Toronto, 620 University Ave, Toronto, Ontario M5G 2C1, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
