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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-9-9
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pubmed:abstractText |
Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don (Bignoniaceae) has been shown to possess anti-microbial, anti-tumoral, and anti-inflammatory properties. Heme oxygenase-1 (HO-1) is a stress response protein and is known to play a protective role against the oxidative injury. In this study, we examined whether catalposide could protect Neuro 2A cells, a kind of neuronal cell lines, from oxidative damage through the induction of HO-1 protein expression and HO activity. The treatment of the cells with catalposide resulted in dose- and time-dependent up-regulations of both HO-1 protein expression and HO activity. Catalposide protected the cells from hydrogen peroxide-induced cell death. The protective effect of catalposide on hydrogen peroxide-induced cell death was abrogated by zinc protoporphyrin IX (ZnPP IX), a HO inhibitor. Additional experiments revealed the involvement of CO in the cytoprotective effect of catalposide-induced HO-1. These results indicate that catalposide is a potent inducer of HO-1 and HO-1 induction is responsible for the catalposide-mediated cytoprotection against oxidative damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bilirubin,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Diuretics,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosides,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Hmox1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/catalposide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-4274
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pubmed:author |
pubmed-author:ChoiByung-MinBM,
pubmed-author:ChungHun-TaegHT,
pubmed-author:KimDae-HanDH,
pubmed-author:KimJong-DuckJD,
pubmed-author:LeeHo-SubHS,
pubmed-author:MoonMi KyoungMK,
pubmed-author:OhCheon-SikCS,
pubmed-author:OhGi-SuGS,
pubmed-author:OhHyuncheolH,
pubmed-author:PaeHyun-OckHO,
pubmed-author:RhoYoung-DeukYD,
pubmed-author:ShinMin-KyoMK
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12962973-Animals,
pubmed-meshheading:12962973-Bilirubin,
pubmed-meshheading:12962973-Blotting, Western,
pubmed-meshheading:12962973-Carbon Monoxide,
pubmed-meshheading:12962973-Cell Line,
pubmed-meshheading:12962973-Cell Survival,
pubmed-meshheading:12962973-Diuretics,
pubmed-meshheading:12962973-Glucosides,
pubmed-meshheading:12962973-Heme Oxygenase (Decyclizing),
pubmed-meshheading:12962973-Heme Oxygenase-1,
pubmed-meshheading:12962973-Hydrogen Peroxide,
pubmed-meshheading:12962973-Iron,
pubmed-meshheading:12962973-Membrane Proteins,
pubmed-meshheading:12962973-Mice,
pubmed-meshheading:12962973-Neurons,
pubmed-meshheading:12962973-Neuroprotective Agents,
pubmed-meshheading:12962973-Oxidants,
pubmed-meshheading:12962973-Oxidative Stress
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pubmed:year |
2003
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pubmed:articleTitle |
Catalposide protects Neuro 2A cells from hydrogen peroxide-induced cytotoxicity via the expression of heme oxygenase-1.
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pubmed:affiliation |
Medicinal Resources Research Center, School of Medicine, Wonkwang University, Iksan,, Chonbuk 570-749 South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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