12962274

Source:http://linkedlifedata.com/resource/pubmed/id/12962274

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006826, umls-concept:C1622572
pubmed:issue	2
pubmed:dateCreated	2003-9-9
pubmed:abstractText	Effective immune strategies for eradication of human malignancies will require a thorough understanding of the interactions of cancer with the immune system. It will be crucial to understand how to optimize and sustain a T cell immune response. Recently, our understanding of the molecular interaction that occurs between an APC and a T cell during cognate interaction has increased dramatically. In this review, various costimulatory and inhibitory molecules of the B7 and TNF families will be discussed. The emphasis will be on how these costimulatory molecules impact T cell activation and on how they can be potentially used for the treatment of cancer.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8712260
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	0883-0185
pubmed:author	pubmed-author:EvansDean EDE, pubmed-author:WeinbergAndrew DAD
pubmed:issnType	Print
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	173-94
pubmed:dateRevised	2004-11-17
pubmed:meshHeading	pubmed-meshheading:12962274-Humans, pubmed-meshheading:12962274-Immunologic Memory, pubmed-meshheading:12962274-Lymphocyte Activation, pubmed-meshheading:12962274-Neoplasms, pubmed-meshheading:12962274-T-Lymphocytes
pubmed:articleTitle	Boosting T cell costimulation in cancer: the possibilities seem endless.
pubmed:affiliation	Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Portland, Oregon 97213, USA.
pubmed:publicationType	Journal Article, Review