Linked Life Data

1296137

Source:http://linkedlifedata.com/resource/pubmed/id/1296137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-4-21
pubmed:abstractText
Genetic modulation of environmental exposures associated with common malignancies is an attractive mechanism to explain differential susceptibility to tobacco or occupation-related carcinogens in the population. The paper reviews the evidence for an association between three genetically based metabolic polymorphisms (N-acetyltransferase, Debrisoquine, hydroxylase, aryl hydrocarbon hydroxylase), which have been implicated in the modulation of lung or bladder cancer risks. Fair to good support emerged for both an association of the acetylation phenotype with occupationally related bladder cancer and for an association of the debrisoquine metabolic phenotype with lung cancer, although in neither case was the evidence completely convincing. Epidemiologic evidence for an association between aryl hydrocarbon hydroxylase and lung cancer is presently problematic because of the difficulties in the assay and subsequent confounding factors.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7818
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
557-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Metabolic polymorphisms and the cancer risk: the evaluation of epidemiological studies].
pubmed:affiliation
Dipartimento di Scienze Biomediche e Oncologia Umana, Ospedale Maggiore, Università di Torino.
pubmed:publicationType
Journal Article, English Abstract, Review